{"id":781,"date":"2023-02-27T16:41:50","date_gmt":"2023-02-27T15:41:50","guid":{"rendered":"https:\/\/lighthousebiotech.com\/?page_id=781"},"modified":"2024-03-21T12:12:18","modified_gmt":"2024-03-21T11:12:18","slug":"rigenera-project","status":"publish","type":"page","link":"https:\/\/lighthousebiotech.com\/en\/rigenera-project\/","title":{"rendered":"Rigenera Project"},"content":{"rendered":"

[et_pb_section fb_built=”1″ fullwidth=”on” _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_fullwidth_header title=”RIGENERA PROJECT” _builder_version=”4.18.0″ _module_preset=”default” title_font=”Roboto||||||||” title_text_align=”center” title_font_size=”50px” background_image=”http:\/\/lighthousebiotech.com\/wp-content\/uploads\/2022\/12\/1-2.png” custom_padding=”100px||100px||false|false” title_text_shadow_style=”preset5″ global_colors_info=”{}”][\/et_pb_fullwidth_header][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.18.0″ _module_preset=”default” background_color=”gcid-b5995a0d-fd76-4221-8695-cb7ffb5d24df” global_colors_info=”{%22gcid-b5995a0d-fd76-4221-8695-cb7ffb5d24df%22:%91%22background_color%22%93}”][et_pb_row _builder_version=”4.18.0″ _module_preset=”default” background_color=”#FFFFFF” width=”96%” custom_margin=”||30px||false|false” custom_padding=”15px|15px|15px|15px|false|false” box_shadow_style=”preset3″ global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.18.0″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.24.2″ _module_preset=”default” header_font_size=”23px” header_line_height=”1.4em” header_font_size_tablet=”23px” header_font_size_phone=”16px” header_font_size_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

Rigenera: platform for the production of decellularized matrices for cardiac regeneration<\/h1>\n

[\/et_pb_text][et_pb_text _builder_version=”4.24.2″ _module_preset=”default” text_font_size=”16px” text_line_height=”1.5em” text_orientation=”justified” text_font_size_tablet=”15px” text_font_size_phone=”13px” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]DESCRIPTION<\/strong><\/p>\n

The project is part of the most recent trends in regenerative medicine (whose goal is to regenerate, replace, or repair damaged tissues or organs), such as the decellularization of animal and human hearts. This means the removal of immunogenic elements, such as cells and their components, while maintaining the native extracellular matrix unchanged in its composition and distribution, including the original vascular and nervous scaffold, necessary to guide subsequent recellularization.<\/p>\n

However, the process is currently unstable, not easily repeatable, operator-dependent, and poorly controlled. In fact, there are no dedicated industrial tools that are easily modifiable for the decellularization of organs, including the heart, and the entire procedure is mostly performed manually.<\/p>\n

The creation of a device capable of combining modularity, sterility, monitoring, and automatic control to perform decellularization, acting on various parameters such as temperature, pressure, and flows, would make the procedure accessible, standardized, and capable of allowing the regeneration of parts of the heart or the whole heart.[\/et_pb_text][et_pb_text _builder_version=”4.24.2″ _module_preset=”default” text_font_size=”16px” text_line_height=”1.5em” text_orientation=”justified” text_font_size_tablet=”15px” text_font_size_phone=”13px” text_font_size_last_edited=”on|phone” global_colors_info=”{}”]OBJECTIVES<\/strong><\/p>\n

The project\u2019s goal is to create a modular and automated platform that, starting from a heart or parts of it, allows the obtaining of a decellularized matrix with preserved intact the original biochemical composition and structure, as well as cellular bioactivity.[\/et_pb_text][et_pb_text _builder_version=”4.24.2″ _module_preset=”default” text_font_size=”16px” text_line_height=”1.5em” text_orientation=”justified” text_font_size_tablet=”15px” text_font_size_phone=”13px” text_font_size_last_edited=”on|phone” ul_line_height_tablet=”” ul_line_height_phone=”1.4em” ul_line_height_last_edited=”on|phone” global_colors_info=”{}”]<\/p>\n

RESULTS<\/strong><\/p>\n